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In one research studying the position of Cdc42 in cervical most cancers, immunohistochemistry was accustomed to detect Cdc42 expression in three forms of tissues: regular cervical tissues, cervical intraepithelial neoplasia (CIN) I or below, CIN II or over, and cervical most cancers tissues.[nine] Cdc42 expression was step by step elevated exhibiting major big difference and was significantly better in HeLa cells than in standard cells.
This subsection of your Sequence area implies In case the canonical sequence shown by default in the entry is in its experienced type or if it signifies the precursor.Extra...Sequence processingi: The displayed sequence is additional processed right into a mature variety.
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Regular most cancers cells and Cdc42-deficient most cancers cells have also been as opposed in vivo. When both of those varieties of cells ended up injected into mouse tail veins, Manage cells distribute out additional around the vessel endothelium in just minutes, suggesting that Cdc42 assists in cell migration.[ten] Right after 6 weeks, the Command cells experienced produced additional metastases when compared to the Cdc42-deficient cells. Invading most cancers cells send out out protrusions that get to down among neighboring endothelial cells to Make contact with the underlying basement membrane.
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"Even further proof of the mutation check out here in CDC42 to be a reason behind a recognizable syndromic sort of thrombocytopenia."
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"The composition of Staufen-made up of RNA granules from human cells suggests their job in the controlled transportation and translation of messenger RNAs."
2odb: The crystal construction of human cdc42 in intricate with the CRIB domain of human p21-activated kinase six (PAK6)
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Employed for statements while in the summary, introduction or dialogue of the paper that can not be traced again to a different publication.
UniProtKB Keyword phrases represent a controlled vocabulary with a hierarchical construction. Keywords and phrases summarise the material of the UniProtKB entry and aid the search for proteins of interest.Additional...Keywordsi
This subsection from the Names and taxonomy portion incorporates the taxonomic hierarchical classification lineage in the resource organism. It lists the nodes as they seem leading-down in the taxonomic tree, Along with the extra basic grouping listed to start with.A lot more...Taxonomic lineagei